Shana Stoddard sitting in front of stained glass windows

Photo by Noah Stewart ’22
 

RESEARCH INTERESTS

Dr. Stoddard’s “Molecular Immunotherapeutics Research” (MIR) lab research program focuses on improving patient outcomes with autoimmune disorders, in particular primary membranous nephritis (PMN), through development of auto-antibody-specific inhibitors, antigen-specific therapies, as well as novel methods for development of antigen specific therapies. The MIR lab also focuses on engineering proteins and design of small compounds that could assist in treatment of cancers, neurological disorders, coronaviruses, and autoimmune disorders. In addition to the design of novel therapies in Stoddard’s MIR lab we develop 3-dimensional models of the proteins associated with these disorders to understand structure function relationships in these protein systems. We use a combination of computational chemistry, biochemistry, cell based-assays, protein engineering, and rational drug design to accomplish our goals.

Research site: Stoddard Molecular Immunotherapeutics Research Lab | Computational and Experimental Bio-Organic Chemistry
 

PUBLICATIONS

Shana V. Stoddard, Serena D. Stoddard, Benjamin K. Oelkers, Kennedi Fitts, Kellen Whalum, Kaylah Whalum, Alexander D. Hemphill, Jithin Manikonda, Linda Michelle Martinez, Elizabeth G. Riley, Caroline M. Roof, Nowreen Sarwar, Doni M. Thomas, Emily Ulmer, Felissa E. Wallace*, Pankaj Pandey, and Sudeshna Roy. Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site. Viruses2020, 12, 942 DOI: 10.3390/v12090942  

Sivaraman Balasubramaniam, Sajith Vijayan, Liam GoldmanXavier A. May, Kyra Dodson, Sweta Adhikari, Fatima Rivas, Davita. L. Watkins, and Shana V. Stoddard. Design and Synthesis of Diazine-based Panobinostat Analogues for HDAC8 Inhibition. Beilstein Journal of Organic Chemistry (2020) 16, 628-637

Shana V. Stoddard, Kyra Dodson, Kamesha Adams, Davita L. Wadkins. In silico Design of Novel Histone Deacetylase 4 Inhibitors: Design Guidelines for Improved Binding Affinity. International Journal of Molecular Sciences, (2020), 21, 219

Elizabeth R. Butch, Paul E. Mead, Victor Amador-Diaz, Heather Tillman, Elizabeth Stewart, Jitendra K. Mishra, Jieun Kim, Armita Bahrami, Jason L.J. Dearling, Alan B. Packard, Shana V. Stoddard, Amy L.Vāvere, Yuanyuan Han, Barry L. Shulkin, and Scott E. Snyder. Variable In Vivo Expression of Disiaganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma Determined Using Positron Emission Tomography. Cancer Research (2019) 79: 1-13

Shana V. Stoddard, Colin L. Welsh, Maggie M. Palopoli, Serena D. Stoddard, Mounika P. Aramandla, Riya M. Patel, and Laurence H. Beck, Jr. Structure and Function Insights Garnered from In silico Modelling of the Thrombospondin Type-1 Domain-Containing 7A Antigen. PROTEINS: Structure, Function, Bioinformatics. (2018) Dec 06. PMID: 30520531

Shana V. Stoddard, Xavier A. May, Fatima Rivas, Kyra Dodson, Sajith Vijayan, Swetha Adhika, Kordarius Parker, Davita L. Watkins.  Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics 37 (2018) 1800080

Shana V. Stoddard, Mark T. Hamann, Randy M. Wadkins. Insights and Ideas Garnered from Marine Metabolites for Development of Acetylcholinesterase and Amyloid-β Aggregation Inhibitors. Marine Drugs 12, (2014) 2114-2131

Shana V. Stoddard, Xiaozhen Yu, Philip M. Potter, Randy M. Wadkins. In Silico Design and Evaluation of Carboxylesterase Inhibitors. Journal of Pesticide Science 35 (2010) 240-249

Latorya D. Hicks, Janice L. Hyatt, Shana Stoddard, Lyudmila Tsurkan, Carol C. Edward, Monika Wierdl, Randy M. Wadkins, Philip M. Potter. Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate CPT-11 Toxicity. Journal of Medicinal Chemistry 52 (2009) 3742-3752

(Names in italics are students; names with asterisks are high school students)
 

Selected Conference Presentations (15 of 67)

Shana V. Stoddard and Carmella N. Stoddard, The Benefits of Enlightenment?: A Strategic Pedagogy for Explicitly Teaching about Diversity and Equity in STEM Classrooms. American Chemical Society (Oral talk) (April 2021)

Adrian Russ, Benjamin Oelkers, Felissa E. Wallace*, Serena D. Stoddard, Qianyi Yi, and Shana V. Stoddard. Protein engineering and optimization of peptide-based therapeutics as RBD binding coronavirus antivirals. American Chemical Society (April 2021)

Felissa E. Wallace*, Serena D. Stoddard, Adrian Russ, Benjamin Oelkers, Qianyi Yi, and Shana V. Stoddard. Protein engineering and optimization of peptide-based therapeutics as HR1 binding coronavirus antivirals. American Chemical Society (April 2021)

Kaylah Whalum, Kathryn Edwards, Qianyi Yi, Serena D. Stoddard, Guadalupe Calderon, Nicole Luthcke, Keerthana Kasetty, and Shana V. Stoddard. Modeling, Characterization, and Classification of Human Thrombospondin Type-1 Like Domains: Evidence for TRP Ladder Functionalization Based on Ladder Type? American Chemical Society (April 2021)

Arrington Moses, Ayanna Kemp, Kelsey Glasper, Kennedi Fitts, Brandon James, Liam Goldman, Xavier May, and Shana V. Stoddard. Developing the perfect fit: Design, Synthesis and Evaluation of Histone Deacetylase Inhibitors for Anti-cancer, Neurological and Autoimmune Therapies. American Chemical Society (April 2021)

Ayanna Kemp, Arrington Moses, Kelsey Glasper, Kennedi Fitts, Brandon James, Liam Goldman, Xavier May, and Shana V. Stoddard. Developing the perfect fit: Design, Synthesis and Evaluation of Histone Deacetylase Inhibitors for Anti-cancer, Neurological and Autoimmune Therapies. National Conference on Undergraduate Research. Bozeman, MT (April 2021)

Keerthana Kasetty, Kathryn Edwards, Qianyi Yi, Serena D. Stoddard, Guadalupe Calderon, Nicole Luthcke, Kaylah Whalum, and Shana V. Stoddard. Modeling, Characterization, and Classification of Human Thrombospondin Type-1 Like Domains: Evidence for TRP Ladder Functionalization Based on Ladder Type? National Conference on Undergraduate Research. Bozeman, MT (April 2021)

Benjamin Oelkers, Felissa E. Wallace*, Adrian Russ, Serena D. Stoddard, Qianyi Yi, and Shana V. Stoddard. Protein engineering and optimization of peptide-based therapeutics as dual site binding coronavirus antivirals National Conference on Undergraduate Research. Bozeman, MT (April 2021)

Shana V. Stoddard, Serena D. Stoddard, Benjamin K. Oelkers, Kennedi Fitts, Kellen Whalum, Kaylah Whalum, Alexander D. Hemphill, Jithin Manikonda, Linda Michelle Martinez, Elizabeth G. Riley, Caroline M. Roof, Nowreen Sarwar, Doni M. Thomas, Emily Ulmer, Felissa E. Wallace*, Pankaj Pandey and Sudeshna Roy, Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site. National Conference on Undergraduate Research. Bozeman, MT (April 2021)

Design, Synthesis, and Effect of Diarylcyclopropane hydroxamic Acids as Histone Deacetylase (HDAC) Inhibitors: Improving Possible Therapy for Huntington’s disease. Jeremy Thelven, Liam Goldman, Shana V. Stoddard, Roberto de la Salud Bea. 46th ACS National Organic Symposium, Bloomington, IN (June 2019)

Colin Welsh and Shana V. Stoddard. In silico Prediction of Immunogenic Sites on PMN Antigen and Design of Epitope Blocking Caps. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Serena D. Stoddard and Shana V. Stoddard. New tools for autoimmune kidney disease: Design of antigen binding proteins against the thrombospondin type-1 containing domain 7A. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Omar Stocks, Liam Goldman, and Shana V. Stoddard. Development of Antigen Binding Protein Monobodies as a Tool for Antigen Specific Treatment for Autoimmune Kidney Disease. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Liam Goldman, Omar Stocks, and Shana V. Stoddard. Epitope Characterization and Design of Epitope Binding Proteins for Idiopathic Membranous Nephropathy: New Tools for Autoimmune Kidney Disease Therapy American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Itthipoaln Rasasack and Shana V. Stoddard. Development of antigen-specific blocking monobodies against the β2-glycoprotein I receptor for the inhibition of systemic lupus erythematosus. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

(Names in italics are students; names with asterisks are high school students)

Education

M.Ed. Freed-Hardeman University (Curriculum and Instruction: emphasis Special Education)
Postdoctoral Researcher St. Jude Children’s Research Hospital (Diagnostic Imaging)
Ph.D. University of Mississippi (Chemistry and Biochemistry)
B.S. Prairie View A&M University (Chemistry)