My lab is the “Molecular Immunotherapeutics Research” (MIR) lab. Our long-term goal is to improve therapy for autoimmune disorders (AD). Autoimmunity is the #2 cause of long-term chronic illness, with over 23.5 million Americans affected. Currently 80-100 autoimmune disorders have been identified by scientists. Idiopathic membranous glomerulonephritis (IMG) is an organ specific AD affecting the kidney glomeruli. It is the most common cause of nephrotic syndrome with over 30-60% of patients progressing to end stage renal disease (ESRD).
My research is focused on improving patient outcomes with autoimmune disorders, in particular idiopathic membranous nephritis (IMN), through development of auto-antibody-specific inhibitors, antigen-specific therapies, as well as novel methods for development of antigen specific therapies. In the MIR lab we accomplish these goals using a combination of computational chemistry, biochemistry, and cell-based assays.
1. Insights and Ideas Garnered from Marine Metabolites for Development of Acetylcholinesterase and Amyloid-β Aggregation Inhibitors, Shana V. Stoddard, Mark T. Hamann, Randy M. Wadkins, Marine Drugs 12, (2014) 2114-2131
2. In Silico Design and Evaluation of Carboxylesterase Inhibitors, Shana V. Stoddard, Xiaozhen Yu, Philip M. Potter, Randy M. Wadkins. Journal of Pesticide Science 35 (2010) 240-249
3. Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate CPT-11 Toxicity, Latorya D. Hicks, Janice L. Hyatt, Shana Stoddard, Lyudmila Tsurkan, Carol C. Edward, Monika Wierdl, Randy M. Wadkins, Philip M. Potter. Journal of Medicinal Chemistry 52 (2009) 3742-3752
1. Development of a 89Zr radiolabeling protocol for an anti-GD2 antibody PET radiotracer using a microfluidics system. Shana V. Stoddard, Amy Vāvere, Kelvin Hammond, and Scott E. Snyder. Annual St. Jude Postdoctoral Research Symposium, Memphis, TN (2015)
2. Preparation and preliminary evaluation of novel GD2 targeting PET radiotracer for patient stratification in Osteosarcoma, Melanoma, and Neuroblastoma: Shana V. Stoddard, Elizabeth R. Butch, Amy, L. Vāvere, Jason L. J. Dearling, Alan B. Packard, Barry L. Shulkin, Scott E. Snyder, Gordon Research Conference, Antibody Biology and Engineering March 24th – 28th, 2014: Tuscany, Italy
3. Insights and Ideas Garnered from Marine Metabolites for Development of Acetylcholinesterase and Amyloid-β Aggregation Inhibitors, Shana V. Stoddard, Mark T. Hamann, Randy M. Wadkins, National Organization for the Professional Advancement of Black Chemists and Chemical Engineers (NOBCChE) national meeting, September – 25th, 2012: Washington, DC.
4. In silico Generation and Evaluation of Carboxylesterase Inhibitor Scaffolds Shana V. Stoddard, Mississippi Academy of Sciences Annual Meeting, February 23rd -24th, 2012: Hattiesburg, MS.
5. Combining Quantitative Structure Activity Relationship (QSAR) Modeling with In silico Design to Develop Carboxylesterase Inhibitors Shana V. Stoddard Midsouth Computational Biology & Bioinformatics Society, 2012: Oxford, MS.
6. Improved, Selective, Human Intestinal Carboxylesterase Inhibitor Designed to Modulate CPT-11 Toxicity, Latorya D. Hicks, Janice L. Hyatt, Shana Stoddard, Lyudmila Tsurkan, Carol C. Edward, Monika Wierdl, Randy M. Wadkins, Philip M. Potter: 61st Southeast Regional Meeting of the ACS (SERMACS), Bioorganic Chemistry Session I, October 21st – October 25th: San Juan, Puerto Rico.
7. Molecular Modeling the Interaction between the Chemical Ligands and Cyclin-Dependent Kinase, Shana Stoddard, Hua-jun Fan: 236th ACS National Meeting, Medicinal Chemistry Division, 2008: Philadelphia, PA.
8. The Expression of the Sialyl Lewis-X Carbohydrate Antigen within the Female Caprine Reproductive Tract, Shana Stoddard, Ramón F. Garcia, NneNna Igbo, Jamila Leake, Selamawit Woldesenbet, Gary Newton, Agricultural Regional Directors Symposium, 2003: Atlanta, GA.
Postdoctoral Researcher St. Jude Children’s Research Hospital (Diagnostic Imaging)
Ph.D. University of Mississippi (Chemistry and Biochemistry)
B.S. Prairie View A&M University (Chemistry)