Shana Stoddard sitting in front of stained glass windows

Photo by Noah Stewart ’22

RESEARCH INTERESTS

My lab is the “Molecular Immunotherapeutics Research” (MIR) lab.  Our long-term goal is to improve therapy for autoimmune disorders (AD).  Autoimmunity is the #2 cause of long-term chronic illness, with over 23.5 million Americans affected.  Currently 80-100 autoimmune disorders have been identified by scientists.  Idiopathic membranous glomerulonephritis (IMG) is an organ specific AD affecting the kidney glomeruli.  It is the most common cause of nephrotic syndrome with over 30-60% of patients progressing to end stage renal disease (ESRD). 

My research is focused on improving patient outcomes with autoimmune disorders, in particular idiopathic membranous nephritis (IMN), through development of auto-antibody-specific inhibitors, antigen-specific therapies, as well as novel methods for development of antigen specific therapies.  In the MIR lab we accomplish these goals using a combination of computational chemistry, biochemistry, and cell-based assays.

Research site: Stoddard Molecular Immunotherapeutics Research Lab | Computational and Experimental Bio-Organic Chemistry

PUBLICATIONS
 

Sivaraman Balasubramaniam, Sajith Vijayan, Liam GoldmanXavier A. May, Kyra Dodson, Sweta Adhikari, Fatima Rivas, Davita. L. Watkins, and Shana V. Stoddard. Design and Synthesis of Diazine-based Panobinostat Analogues for HDAC8 Inhibition. Beilstein Journal of Organic Chemistry (2020) 16, 628-637

Shana V. Stoddard, Kyra Dodson, Kamesha Adams, Davita L. Wadkins. In silico Design of Novel Histone Deacetylase 4 Inhibitors: Design Guidelines for Improved Binding Affinity. International Journal of Molecular Sciences, (2020), 21, 219

Elizabeth R. Butch, Paul E. Mead, Victor Amador-Diaz, Heather Tillman, Elizabeth Stewart, Jitendra K. Mishra, Jieun Kim, Armita Bahrami, Jason L.J. Dearling, Alan B. Packard, Shana V. Stoddard, Amy L.Vāvere, Yuanyuan Han, Barry L. Shulkin, and Scott E. Snyder. Variable In Vivo Expression of Disiaganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma Determined Using Positron Emission Tomography. Cancer Research (2019) 79: 1-13

Shana V. Stoddard, Colin L. Welsh, Maggie M. Palopoli, Serena D. Stoddard, Mounika P. Aramandla, Riya M. Patel, and Laurence H. Beck, Jr. Structure and Function Insights Garnered from In silico Modelling of the Thrombospondin Type-1 Domain-Containing 7A Antigen. PROTEINS: Structure, Function, Bioinformatics. (2018) Dec 06. PMID: 30520531

Shana V. Stoddard, Xavier A. May, Fatima Rivas, Kyra Dodson, Sajith Vijayan, Swetha Adhika, Kordarius Parker, Davita L. Watkins.  Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics 37 (2018) 1800080

Shana V. Stoddard, Mark T. Hamann, Randy M. Wadkins. Insights and Ideas Garnered from Marine Metabolites for Development of Acetylcholinesterase and Amyloid-β Aggregation Inhibitors. Marine Drugs 12, (2014) 2114-2131

Shana V. Stoddard, Xiaozhen Yu, Philip M. Potter, Randy M. Wadkins. In Silico Design and Evaluation of Carboxylesterase Inhibitors. Journal of Pesticide Science 35 (2010) 240-249

Latorya D. Hicks, Janice L. Hyatt, Shana Stoddard, Lyudmila Tsurkan, Carol C. Edward, Monika Wierdl, Randy M. Wadkins, Philip M. Potter. Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate CPT-11 Toxicity. Journal of Medicinal Chemistry 52 (2009) 3742-3752

(Names in italics are students)
 

Conference Presentations (10 of 50)

 

Structural Study of Neural Cadherin Dimerization. Anter A. Shami, Addison E. Roush, Samantha Davila, Peilu Liu, Alan G. Marshall, Shana V. Stoddard, Joshua S. Sharp, Susan Pedigo. American Society of Mass Spectormetry. Houston, TX (May 2020)

Design, Synthesis, and Effect of Diarylcyclopropane hydroxamic Acids as Histone Deacetylase (HDAC) Inhibitors: Improving Possible Therapy for Huntington’s disease. Jeremy Thelven, Liam Goldman, Shana V. Stoddard, Roberto de la Salud Bea. 46th ACS National Organic Symposium, Bloomington, IN (June 2019)

Colin Welsh and Shana V. Stoddard. In silico Prediction of Immunogenic Sites on PMN Antigen and Design of Epitope Blocking Caps. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Serena D. Stoddard and Shana V. Stoddard. New tools for autoimmune kidney disease: Design of antigen binding proteins against the thrombospondin type-1 containing domain 7A. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Omar Stocks, Liam Goldman, and Shana V. Stoddard. Development of Antigen Binding Protein Monobodies as a Tool for Antigen Specific Treatment for Autoimmune Kidney Disease. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Liam Goldman, Omar Stocks, and Shana V. Stoddard. Epitope Characterization and Design of Epitope Binding Proteins for Idiopathic Membranous Nephropathy: New Tools for Autoimmune Kidney Disease Therapy American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Itthipoaln Rasasack and Shana V. Stoddard. Development of antigen-specific blocking monobodies against the β2-glycoprotein I receptor for the inhibition of systemic lupus erythematosus. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Aryan Galani and Shana V. Stoddard. Design of antibody-blocking monobodies: A novel therapeutic approach for autoimmune kidney disease. American Society for Biochemistry and Molecular Biology Annual National Meeting. Orlando, FL (April 2019)

Shana V. Stoddard. Computational Insights into the Structure and Epitope locations for Two Idiopathic Membranous Nephropathy Antigens: Phospholipase A2 Receptor and the Thrombospondin Type-1 Containing Domain 7A and Design of Antigen Binding Proteins. American Society for Biochemistry and Molecular Biology Annual National Meeting. San Diego, CA (April 2018)

Barry Rich, Emma Goldman, Caylon Martin*, Shana V. Stoddard, Kimberly A. Brien. Synthesis and Computational Evaluation of Vorinostat Boron Derivatives as Potential Histone Deacetylase Inhibitors. 255th ACS National Meeting, New Orleans, LA (March 2018)

*Student with Asterisk (Grad Academy High School Student)

Education

M.Ed. Freed-Hardeman University (Curriculum and Instruction: emphasis Special Education)
Postdoctoral Researcher St. Jude Children’s Research Hospital (Diagnostic Imaging)
Ph.D. University of Mississippi (Chemistry and Biochemistry)
B.S. Prairie View A&M University (Chemistry)