Shana Stoddard

Photo by Noah Stewart ’22
 

RESEARCH INTERESTS

Dr. Stoddard’s “Molecular Immunotherapeutics Research” (MIR) lab research program focuses on improving patient outcomes with autoimmune disorders, in particular primary membranous nephritis (PMN), through development of auto-antibody-specific inhibitors, antigen-specific therapies, as well as novel methods for development of antigen specific therapies. The MIR lab also focuses on engineering proteins and design of small compounds that could assist in treatment of cancers, neurological disorders, coronaviruses, and autoimmune disorders. In addition to the design of novel therapies in Stoddard’s MIR lab we develop 3-dimensional models of the proteins associated with these disorders to understand structure function relationships in these protein systems. We use a combination of computational chemistry, biochemistry, cell based-assays, protein engineering, and rational drug design to accomplish our goals.

Research site: Stoddard Molecular Immunotherapeutics Research Lab | Computational and Experimental Bio-Organic Chemistry
 

PUBLICATIONS

Stoddard SV. The Benefits of Enlightenment: A Strategic Pedagogy for Explicitly Teaching about Diversity and Equity in STEM Classrooms. Education Sciences, 2022, 12(7), 498 

Stoddard SV, Wallace FE*, Stoddard SD‡, Cheng Q, Acosta D, Barzani S, Bobay M, Briant J, Cisneros C, Feinstein S, Glasper K, Hussain M, Lidoski A, Lingareddy P, Lovett G, Matherne L, McIntosh J, Moosani N, Nagge L, Nyamkondiwa K, Pratt I, Root E, Rutledge MR, Sawyer M, Singh Y, Smith K, Tanveer U, and Vaghela S. In silico design of peptide-based SARS-CoV-2 fusion inhibitors that target WT and mutant versions of SARS-CoV-2 HR1 domains. Biophysica, 2021, 1, 311

Stoddard SV, Stoddard SD, Oelkers BK, Fitts K, Whalum K1, Whalum K2, Hemphill AD, Manikonda J, Martinez LM, Riley EG, Roof CM, Sarwar N, Thomas DM, Ulmer E, Wallace FE*, Pandey P, and Roy S. Optimization Rules for SARS-CoV-2 Mpro Antivirals: Ensemble Docking and Exploration of the Coronavirus Protease Active Site. Viruses, 2020, 12, 942 

Balasubramaniam S, Vijayan S, Goldman L, May XA, Dodson K, Adhikari S, Rivas F, Watkins DL, and Stoddard SV. Design and Synthesis of Diazine-based Panobinostat Analogues for HDAC8 Inhibition. Beilstein Journal of Organic Chemistry, 2020, 16(1), 628-637 

Stoddard SV, Dodson K, Adams K, Wadkins DL. In silico Design of Novel Histone Deacetylase 4 Inhibitors: Design Guidelines for Improved Binding Affinity. International Journal of Molecular Sciences, 2020, 21(1), 219 

Butch ER, Mead PE, Amador-Diaz V, Tillman H, Stewart E, Mishra JK, Kim J, Bahrami A, Dearling JLJ, Packard AB, Stoddard SV, Vāvere AL, Han Y, Shulkin BL, and Snyder SE. Variable In Vivo Expression of Disiaganglioside GD2 in Mouse Models of Primary and Metastatic Osteosarcoma Determined Using Positron Emission Tomography.  Cancer Research, 2019 79(12), 3112-3124 

Stoddard SV, Welsh CL, Palopoli MM, Stoddard SD, Aramandla MP, Patel RM, and Beck, Jr. LH. Structure and Function Insights Garnered from In silico Modelling of the Thrombospondin Type-1 Domain-Containing 7A Antigen.  PROTEINS: Structure, Function, Bioinformatics, 2019, 87(2), 136-145 

Stoddard SV, May XA, Rivas F, Dodson K, Vijayan S, Adhika S, Parker K, Watkins DL.  Design of Potent Panobinostat Histone Deacetylase Inhibitor Derivatives: Molecular Considerations for Enhanced Isozyme Selectivity between Histone Deacetylase 2 (HDAC2) and Histone Deacetylase 8 (HDAC8). Molecular Informatics 38(3) 2018, 1800080 

Stoddard SV, Hamann MT, Wadkins RM. Insights and Ideas Garnered from Marine Metabolites for Development of Acetylcholinesterase and Amyloid-β Aggregation Inhibitors. Marine Drugs 12, (2014) 2114-2131 

Stoddard SV, Yu X, Potter PM, Wadkins RM. In Silico Design and Evaluation of Carboxylesterase Inhibitors. Journal of Pesticide Science 35 2010 240-249

Hicks LD, Hyatt JL, Stoddard SV, Tsurkan L, Edward CC, Wierdl M, Wadkins RM, Potter PM. Improved, Selective, Human Intestinal Carboxylesterase Inhibitors Designed to Modulate CPT-11 Toxicity. Journal of Medicinal Chemistry 52 (2009) 3742-3752

(Post-Baccalaureate co-authors indicated by an ‡; Undergraduate co-authors underlined; High school co-authors indicated by an *)

Honors, Awards, and Media Appearances

2022 – Henry C. McBay Outstanding Teaching Award, The National Organization for the Professional

Advancementof Black Chemists and Chemical Engineers (NOBCChE)

2022 – Researcher Highlight in ASBMB Today Magazine April/May issue.

2021 – Highlighted in ASBMB Today Magazine for CUR Mentoring award May issue

2021 – Accessibility and Inclusivity Advocate of the Year: Campus Life Award (Rhodes College)

2021 – Outstanding Mentor of the year Award CUR Health Sciences (Early Career Stage)

2021 – “A year after COVID-19 shut schools, students and teachers share what shook them – and what

strengthened them” USA Today News [Video and online print article] (Mar 21st, 2021)

2021 – “COVID-19 Treatment and Foundational Chemistry” The Academic Minute of the Association of

American Colleges & Universities produced by WAMC Northeast Public Radio. (Jan 27th, 2021)

2020 – “Rhodes students research COVID-19 treatments.” Featured in Daily Memphian news story, Healthcare and Higher Education section. [Article] (Sep 1st, 2020)

2020 – Selected through a competitive process to participate in Project Kaleidoscope STEM Leadership Institute held by the American Association of Colleges and Universities for individuals interested in developing leadership skills to advance and reform undergraduate STEM education.

2020 – “Level Up: Increasing the number of women in STEM careers through mentorship.” FOX13 Memphis broadcast feature news story (Feb 25th, 2020)