Le Research Group / Organic Synthetic Chemistry

Research in our laboratory focuses on the development of new methods for the preparation of small molecules with significant therapeutic properties.  Our current targets ranging from antimalarial agent, febrifugine to precursor of a-glucosidase inhibitor, gabosine I.  The plan is to design a diversity oriented synthesis for the synthesis of these molecules and their analogues for in sufficient quantities for further biological testing and structure-activity relationship studies.  Research experiences will also include experimental design and modern methods of purification and structural characterization.

Research Students Past and Present

Fall 2007:

 

Left to Right: Griffin Morrisson, Susan Wang, Kelly Hoth, Shruti Acharya and Lane Lovett 

Griffin Morrisson (Chemistry ′08)

Project:  From glucose to gasobine I, a precursor to alpha-glucosidase inhibitor  

Susan Wang (Chemistry ′08)             

Project:  From glucose to gasobine I, a precursor to alpha-glucosidase inhibitor  

                                                     

Kelly Hoth (Chemistry and Biology, ′08)            

Project:  Studies directed toward the synthesis of gabosine E, a potential cholesterol lowering drug                                  

Shruti Acharya (Chemistry and Biology, ′08)

Project:  Studies directed toward the synthesis of gabosine E, a potential cholesterol lowering drug

Lane Lovett (BMB, ′09)

Project:  Febrifugine, a natural product with potent antimalaria activity

Past Members

   

Lori Culberson (Chemistry ′08)

Sonal Patel (Chemistry ′08)

   

Ke Qi (Biology ′07)