Larryn Peterson | Assistant Professor
Office: Kennedy 409 | Phone: (901) 843-3545 | Email: petersonl@rhodes.edu

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Research in the Peterson lab uses an interdisciplinary approach to understand important biological processes by utilizing tools from synthetic organic chemistry, chemical biology, biochemistry and molecular biology. We currently have two projects ongoing in our lab: 1) investigating the substrate of selectivity of sulfotransferases, a class of enzymes that play a critical role in the regulation and activities of many endogenous molecules including neurotransmitters and hormones, as well as the xenobiotics, and 2) probing the active site requirements of LpxC, an enzyme involved in the biosynthesis of Lipid A, an integral component of Gram-negative bacteria cell walls.


Education

Post-Doctoral Researcher, Stanford University
Ph.D. University of Southern California (Bioorganic Chemistry)
B.A. Carroll College (Chemistry)


Courses

Chemistry 211 - ORGANIC CHEMISTRY I
Chemistry 212 - ORGANIC CHEMISTRY II
Chemistry 212 - ORGANIC CHEMISTRY II LAB
Chemistry 422 - ADVANCED ORGANIC CHEMISTRY 
Chemistry 451 - INTRODUCTION TO RESEARCH
Chemistry 486 - CHEMISTRY SENIOR SEMINAR


Selected Publications

1.   L.W. Peterson, J.-S. Kim, S. Mitchell, P. Kijek, J.M. Breitenbach, K.Z. Borysko, J.C. Drach, J.M. Hilfinger, B.A. Kashemirov, C.E. McKenna. Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir. Bioorganic & Medicinal Chemistry Letters 2011, 21(13), 4045-4049. DOI:  10.1016/j.bmcl.2011.04126

2. V.M. Zakharova, M. Serpi, I.S. Krylov, L.W. Peterson, J.M. Breitenbach, K.Z. Borysko, J.C. Drach, M. Collins, J.M. Hilfinger, B.A. Kashemirov, C.E. McKenna. Tyr-based (S)-HPMPC and (S)-HPMPA prodrugs: Synthesis, stability, antiviral activity and in vivo transport studies. Journal of Medicinal Chemistry, 2011, 54(16), 5680-5693. DOI: 10.1021/jm2001426.

3. L.W. Peterson*, M. Sala-Rabanal*, I.S. Krylov, M. Serpi, B.A. Kashemirov, C.E. McKenna. Serine side chain-linked peptidomimetic prodrugs of cyclic cidofovir: Synthesis and interaction with hPEPT1. Molecular Pharmaceutics 2010, 7(6), 2349-2361. DOI: 10.1021/mp100186b

4. C.E. McKenna, B.A. Kashemirov, L.W. Peterson, M.F. Goodman. Modifications to the dNTP triphosphate moiety: From mechanistic probes for DNA polymerases to anti-viral and anti-cancer drug design. Biochimica et Biophysica Acta-Proteins and Proteomics 2010, 1804(5), 1223-1230.  DOI: 10.1016/j.bbapap.2010.01.005

5.  U. Tehler, C.S. Hartz, L.W. Peterson, C.J. Provoda, J.M. Hilfinger, K.-D. Lee, C.E. McKenna, G.L. Amidon. Puromycin-sensitive aminopeptidase (PSA): An antiviral prodrug activating enzyme. Antiviral Research 2010, 85(3), 482-489. DOI: 10.1016/j.antiviral.2009.12.003

6.  L.W. Peterson and C.E. McKenna. Prodrug approaches to improving the oral absorption of antiviral nucleotide analogues. Expert Opinion on Drug Delivery 2009, 6(3), 405-420. DOI: 10.1517/17425240902824808

7.  U. Eriksson, L.W. Peterson, B.A. Kashemirov, J.M. Hilfinger, J.C. Drach, K. Borysko, J. Breitenbach, J.-S. Kim, S. Mitchell, P. Kijek, C.E. McKenna. Serine peptide phosphoester prodrugs of cyclic cidofovir:  synthesis, transport and antiviral activity. Molecular Pharmaceutics 2008, 5(4), 598-609. DOI: 10.1021/mp8000099