My research focuses on investigating regulatory mechanisms of eukaryotic gene expression. Currently, my laboratory is focusing on genes that are involved in fungal cell wall metabolism. The fungal cell wall, which is composed of polysaccharides and glycoproteins, is essential for growth and metabolism of the fungus and is an excellent target for antifungal drugs. We have identified several genes that play specific roles in cell wall metabolism in the filamentous fungus Aspergillus nidulans including genes that have homologues that have been found to be involved in establishing and maintaining cell wall integrity in yeasts and several other previously uncharacterized genes. Experiments are being conducted to investigate the regulation of message production of these genes, to observe the cellular localization of the proteins during different stages of fungal development, and to learn more about the specific role of each of them in cell wall metabolism.
Links to CollaboratorsRead more about Prof. Jackson-Hayes′ research group »
Ph.D. University of Tennessee, Memphis (Pharmacology)
B.S. Tougaloo College (Chemistry)
- BMB 451 - RESEARCH
- Chemistry 120 - FOUNDATIONS OF CHEMISTRY
- Chemistry 111 - FOUNDATIONS OF CHEMISTRY LAB
- Chemistry 416 - MECHANISMS OF DRUG ACTION
- Chemistry 451 - INTRODUCTION TO RESEARCH
- Chemistry 452 - INTRODUCTION TO RESEARCH
- Chemistry 485 - SENIOR SEMINAR
- Chemistry 495 - HONORS RESEARCH
Loretta Jackson-Hayes, Shulan Song, Eduard N. Lavrentyev, Michelle S. Jansen, F. Bradley Hillgartner, Liquin Tian, Philip A. Wood, George A. Cook, and Edwards A. Park, "A Thyroid Hormone Response Unit Formed between the Promoter and First Intron of the Carnitine Palmitoyltransferase-I Gene Mediates the Liver-specific Induction by Thyroid Hormone", J. Biol. Chem. 2003, 278, 7964.
Shulan Song, Yi Zhang, Ke Ma, Loretta Jackson-Hayes, Eduard N. Lavrentyev, George A. Cook, Marshall B. Elam, and Edwards A. Park, “Peroxisomal Proliferator Activated Receptor Gamma Coactivator (PGC-1 alpha) Stimulates Carnitine Palmitoyltransferase-I (CPT-I alpha) through the First Intron”, Biochim. Biophys. Acta. 2004, 1679(2), 164.
Loretta Jackson-Hayes, Terry W. Hill, Darlene M. Loprete, Barbara S. Gordon, Chassidy J. Groover, Laura R. Johnson, Stuart A. Martin. (2010) “GDP-mannose transporter paralogues play distinct roles in polarized growth of Aspergillus nidulans.” Mycologia, 102(2), 305.
Loretta Jackson-Hayes, Lauren M. Fay, Barbara Gordon, Stuart Martin, Sonia Nkashama, Ravi Patel, Stanley R. Vance, Caroline V. Sartain, Terry W. Hill, and Darlene M. Loprete. (2008) “Two GDP-mannose transporters contribute to cell wall integrity in Aspergillus nidulans.” Microbiology 154, 2037.
57 th Southeast / 61 st Southwest Joint Regional Meeting of the American Chemical Society, November 1-5, 2005, Memphis, TN
Title: Putative mannose transporters contribute to cell wall stability in Aspergillus nidulans.
Loretta Jackson-Hayes, Lauren Faye, Terry W. Hill, and Darlene M. Loprete
American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting (national/international), April 1-5, 2006, San Francisco, CA
Title: Putative mannose transporters are involved in establishing cell wall integrity in Aspergillus nidulans.
Loretta Jackson-Hayes, Lauren Faye, Caroline Sartain, Terry W. Hill and Darlene M. Loprete
24th Fungal Genetics Conference, March 20-25, 2007, Asilomar Conference Center, Pacific Grove, CA
Title: Putative mannose transporters complement a branching/septation defect in Aspergillus nidulans.
Loretta Jackson-Hayes, Lauren Fay, Terry W. Hill and Darlene M. Loprete